Härkönen H.H., Mattson J.M., Määttä J.A., Stenman U.H., Koistinen H., Matero S., Windshügel B., Poso A., Lahtela-Kakkonen M.
The Discovery of Compounds that Stimulate the Activity of Kallikrein-Related Peptidase 3 (HLK3).
ChemMedChem. 2011 Dec 9;6(12):2170-8 [Abstract] 

Halley F., Reinshagen J., Ellinger B., Wolf M., Niles A., Evans N.J., Kirkland T.A., Wagner J.M., Jung M., Gribbon P., Gul S.
A Bioluminogenic HDAC Activity Assay: Validation and Screening.
J Biomol Screen. 2011. Epub 2006 Aug 10. [Abstract] 

Preißl S. , Bick I., Obrdlik P., Diekert K., Gul S., Gribbon P.
Development of an Assay for Complex I/Complex III of the Respiratory Chain Using Solid Supported Membranes and Its Application in Mitochondrial Toxicity Screening in Drug Discovery.
Assay Drug Dev Technol. 2011 Apr;9(2):147-156. [Abstract] 

Gul S., Gribbon P.
Exemplification of the challenges associated with utilising fluorescence intensity based assays in discovery.
Expert Opin. Drug Discov. 2010 5(7):681-690.  

Mayer G, Faulhammer D, Grättinger M, Fessele S, Blind M.
A RNA-based approach towards small molecule inhibitors.
Chembiochem. 2009 Aug;10(12):1993-1996. [Abstract]

Hassan N., Gul S., Flett F., Hollingsworth E., Dunne A., Emmons A.J., Hutchinson J., Hibbs M., Tew D., Powell D.J. & Morse M.
Development of an insect cell-based assay for detection of kinase inhibition using NF-kappaB inducing kinase as a paradigm.
Biochemical Journal 2009 Apr 1;419(1):65-73. [Abstract]

Heng BC, Gribbon PM, Day AJ, Hardingham TE.
Hyaluronan binding to link module of TSG-6 and to G1 domain of aggrecan is differently regulated by pH.
J Biol Chem. 2008 Nov 21;283(47):32294-301. Epub 2008 Sep 19. [Abstract]

Gribbon P.
High throughput hit finding and compound profiling technologies for academic drug discovery
Drug Discov Today: Technologies. 2008 vol.5(1):e3-e7.

Moger J, Gribbon P, Sewing A, Winlove CP.
Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of tyrosine and serine phosphorylation.
Biochim Biophys Acta. 2007 Jun;1770(6):912-8. Epub 2007 Feb 12. [Abstract]

Moger J, Gribbon P, Sewing A, Winlove CP.
The application of fluorescence lifetime readouts in high-throughput screening.
J Biomol Screen. 2006 Oct;11(7):765-72. Epub 2006 Aug 30. [Abstract]

Nowlin D, Bingham P, Berridge A, Gribbon P, Laflin P, Sewing A.
Analysing the output from primary screening.
Comb Chem High Throughput Screen. 2006 Jun;9(5):331-7. [Abstract]

Gribbon P, Chambers C, Palo K, Kupper J, Mueller J, Sewing A.
A novel method for analyzing [Ca2+] flux kinetics in high-throughput screening.
J Biomol Screen. 2006 Aug;11(5):511-8. Epub 2006 Jun 7. [Abstract]

Porschewski P, Grättinger MA, Klenzke K, Erpenbach A, Blind MR, Schäfer F.
Using aptamers as capture reagents in bead-based assay systems for diagnostics and hit identification.
J Biomol Screen. 2006 Oct;11(7):773-81. Epub 2006 Aug 30. [Abstract]

Gribbon P, Schaertl S, Wickenden M, Williams G, Grimley R, Stuhmeier F, Preckel H, Eggeling C, Kraemer J, Everett J, Keighley WW, Sewing A.
Experiences in implementing uHTS--cutting edge technology meets the real world.
Curr Drug Discov Technol. 2004 Jan;1(1):27-35. Review. [Abstract]

Gribbon P, Lyons R, Laflin P, Bradley J, Chambers C, Williams BS, Keighley W, Sewing A.
Evaluating real-life high-throughput screening data.
J Biomol Screen. 2005 Mar;10(2):99-107. [Abstract]

Gribbon P, Sewing A.
High-throughput drug discovery: what can we expect from HTS?
Drug Discov Today. 2005 Jan 1;10(1):17-22. Review. [No abstract available]

Gul, S., Brown, R., May, E., Mazzulla, M., Smyth, M.G., Berry, C., Morby, A. & Powell, D.
Staphylococcus aureus DNA ligase: Characterization of its kinetics of catalysis and development of a high
throughput screening compatible chemiluminescent hybridisation protection assay.
Biochemical Journal, 2004, 383, 551-559. [Abstract]

Gribbon P, Sewing A.
Fluorescence readouts in HTS: no gain without pain?
Drug Discov Today. 2003 Nov 15;8(22):1035-43. Review. [Abstract]

For reprint requests please contact: contact(at)screeningport.com
 

Commisioned Work

Claussen C. 
Zellbasierte Technologien im HT-Screening. Transkript SPEZIAL - Industrielle Zelltechnik, Juli, 7-8, 2011.

Müller FJ, Gribbon P.
Pathway-based Target Identification and Validation. Screening, 4/2009,14-15.

Claussen C.
Innovation Welcome! Screening, 4/2009,3.

Alton GR, Bowes S, Gul S, Molloy C.
Lab Automation Roundtable. European Pharmaceutical Review, 2009, 6, 58-62.

Gul S.
Development and implementation of an automated compound screening activities facility. European Pharmaceutical Review, 2009, 2, 47-50.

Graettinger M., Gribbon P., Lenz J., Frank R., von Kries JP., Kuehne R. and Rademann J.
Advancing Academic Drug Discovery. Screening, 2/2009,17-19.

Gul S.
Lab Automation Series, European Pharmaceutical Review Digital:

Article 1: Advances in the design and development of automation solutions in High Throughput Screening. 2009, 1.

Article 2: The use of microfluidics to facilitate Drug Discovery efforts. 2009, 2.

Article 3: Account of cell based assays and suitable cytotoxicity assays to facilitate Drug Discovery efforts. 2009, 3.

Article 4: Trends associated with the development of catalytic assays for disease related enzymes in early stage Drug Discovery. 2009, 4.

Article 5: Procedures for setting up automation to facilitate Drug Discovery efforts. 2009, 5.

Article 6: Milestones in pre-clinical Drug Discovery. 2009, 6.

Gul S.
The role of liquid handling technologies in successfully executing screening campaigns. European Pharmaceutical Review, 2008, 6, 50-54.

Gul S. & Gribbon P.
Applying automation in early drug discovery: lessons learnt and future perspectives. European Pharmaceutical Review, 2008, 5, 32-36.

For reprint requests please contact: contact(at)screeningport.com

Chapters and Books

Brocklehurst K., Gul S. & Pickersgill R.W., Ed. Hughes A.B.
Substrate Recognition in Amino Acids, Peptides and Proteins in Organic Chemistry.
Wiley-VCH publishers, 2009, vol.2, 473-504.

Deryk Streich, Dorothee Wahl
Innovationsfähigkeit in einer modernen Arbeitswelt – Beiträge der Tagung des BMBF:
Risikobereitschaft und Veränderungsmanagement bei Technologieunternehmen, by Carsten Claussen
Campus Verlag, 2007.